ENCEFALOPATIA, LATTULOSIO O LATTULOSIO / RIFA: UN PICCOLO STUDIO DI REAL WORLD EVIDENCE

Real-World Experience of the One-Year Efficacy of Rifaximin Add-On to Lactulose Is Superior to Lactulose Alone in Patients with Cirrhosis Complicated with Recurrent Hepatic Encephalopathy in Taiwan Ching Chang et al. Abstract Background: Hepatic encephalopathy (HE), a neuropsychiatric complication of decompensated cirrhosis, is associated with high mortality and high risk of recurrence. Rifaximin add-on to lactulose…

LA PANDEMIA HA FATTO ESPLODERE UNA CATTIVA “SCIENZA “: UN OTTIMO COMMENTO DI “WIRED”

La cattiva scienza che la pandemia ci ha portato di Viola Rita A fronte di grandi passi in avanti, una fetta rilevante della ricerca clinica non è stata di buona qualità. Le ragioni riguardano un approccio obsoleto alle sperimentazioni, inclusa la mancanza di collaborazione e di coordinamento, insieme a ostacoli normativi. Ma c’è un modello cui…

CHIRURGIA OPEN O LAPAROSCOPICA PER LE FISTOLE DA MALATTIA DIVERTICOLARE: UNA REVISIONE SISTEMATICA ED UN’OTTIMA META-ANALISI !

Open versus laparoscopic surgery for the treatment of diverticular colovesical fistulas: A systematic review and meta-analysis Mario Trejo-Avila, Omar Vergara-Fernández BACKGROUND: The aim of this study was to analyze the evidence regarding open versus laparoscopic surgery for the treatment of diverticular colovesical fistula (CVF) in terms of perioperative outcomes. METHODS: A systematic review was performed using PubMed,…

UNO STUDIO DI REAL WORLD EVIDENCE SULLA DURATA DEGLI ANTICORPI ANTI COVID-19 NEGLI USA: RIMANGONO FINO A 10 MESI !

A population-based analysis of the longevity of SARS-CoV-2 antibody seropositivity in the United States David Alfego, Adam Sullivan, Brian Poirier, Jonathan Williams, Dorothy Adcock, Stanley Letovsky Background: This cross-sectional study aimed to track population-based SARS-CoV-2 antibody seropositivity duration across the United States using observational data from a national clinical laboratory registry of patients tested by nucleic…

IL MONITORAGGIO DEI METABOLITI DELL’AZATIOPRINA CAMBIA LA GESTIONE CLINICA NELLE IBD! UNO STUDIO DI REAL WORLD EVIDENCE

Real-World Use of Azathioprine Metabolites Changes Clinical Management of Inflammatory Bowel Disease Laura Wilson, Stephanie Tuson, Lufang Yang, Dustin Loomes Background: Thiopurines such as 6-mercaptopurine and azathioprine have complex metabolism, resulting in significant inter-individual differences in clinical efficacy and risk of drug toxicity, making conventional weight-based dosing inaccurate and potentially unsafe. Therapeutic drug monitoring (TDM) of…

INCONSISTENZA DELLE LINEE GUIDA SULLE NEOPLASIE CISTICHE DEL PANCREAS: UNA GRANDE “SURVEY” SU EVIDENZA E PRATICA CLINICA DAL “VERONA EBM 2020 ON IPMN”

Guidelines on Pancreatic Cystic Neoplasms: Major Inconsistencies With Available Evidence and Clinical Practice— Results From an International Survey Giovanni Marchegiani Roberto Salvia On behalf of the Verona EBM 2020 on IPMN Epidemiologic studies have estimated that between 2% and 45% of the general population harbor a pancreatic cyst. Pancreatic cystic neoplasms (PCNs) encompass a wide…