Dalla RWE alle strategie di prevenzione: le disuguaglianze di salute negli immigrati residenti in una ASL italiana

From the “real-world evidence” to prevention strategies: health inequalities in immigrants residing in an Italian Local Health Unit Mario Muselli1,  Vincenza Cofini1 ,  Chiara Berra1,  Cristina Carmignani1,  Leondino Mammarella2,  Stefano Necozione1 Department of Life, Health and Environmental Sciences, University of L’Aquila (Italy) Local Health Unit No.1 Avezzano-Sulmona-L’Aquila, L’Aquila (Italy) ABSTRACT OBJECTIVES: to assess the health inequalities of immigrants in the…

Generazione di RWE da note cliniche non strutturate per esaminare l’utilità clinica dei test genetici: caso d’uso in BRCAness

Generating real-world evidence from unstructured clinical notes to examine clinical utility of genetic tests: use case in BRCAness Yiqing Zhao1, Saravut J Weroha2, Ellen L Goode3, Hongfang Liu1, Chen Wang4 Abstract Background: Next-generation sequencing provides comprehensive information about individuals’ genetic makeup and is commonplace in oncology clinical practice. However, the utility of genetic information in the clinical decision-making process has…

La Real World Evidence richiede un’attenta interpretazione

Real-world Evidence Needs Careful Interpretation Peter Nash The Journal of Rheumatology January 2021, 48 (1) 1-2; DOI: https://doi.org/10.3899/jrheum.201004 The Janus kinase (JAK) inhibitors have proven to be popular across the globe for an increasing variety of autoimmune inflammatory disorders seen in rheumatology, dermatology, and gastroenterology1. In patients with rheumatoid arthritis (RA), market share is on the rise in many countries,…

Encefalopatia epatica: nuovi approfondimenti sulla classificazione, fisiopatologia e terapia

Hepatic encephalopathy: Novel insights into classification, pathophysiology and therapy Christopher F. Rose ; Piero Amodio ; Jasmohan S. Bajaj ; Simon D. Taylor-Robinson ; Hendrik Vilstrup ; Rajiv Jalan Summary Hepatic encephalopathy (HE) is a frequent and serious complication of both chronic liver disease and acute liver failure. HE manifests as a wide spectrum of neuropsychiatric abnormalities,…

Alterazioni nel microbioma intestinale nella cirrosi come valutate dalla metagenomica quantitativa: relazione con insufficienza epatica acuta su cronica e prognosi

Alterations in Gut Microbiome in Cirrhosis as Assessed by Quantitative Metagenomics: Relationship With Acute-on-Chronic Liver Failure and Prognosis Cristina Solé ; Susie Guilly ; Kevin Da Silva ; Elsa Solà; Stanislav Dusko Ehrlich ; Pere Ginès Background and Aims Cirrhosis is associated with changes in gut microbiome composition. Although acute-on-chronic liver failure (ACLF) is the most severe clinical stage…

Epidemiologia della malattia diverticolare: aumento dei tassi di mortalità della malattia diverticolare nelle nazioni in via di sviluppo

Diverticular Disease Epidemiology: Rising Rates of Diverticular Disease Mortality Across Developing Nations Cameron W Hunt1, Ruchir Chaturvedi, Lev Brown, Caitlin Stafford, Christy E Cauley, Robert N Goldstone, Todd D Francone, Hiroko Kunitake, Liliana Bordeianou, Rocco Ricciardi Abstract BACKGROUND: The incidence of diverticular disease is growing in the Western world. However, the global burden of disease is unknown in the developing world. OBJECTIVE: This study…